The antibiotics such as tetracycline, erythromycin, clindarnycin and cotrirpoxazole are most commonly used in the treatment of acne vul¬garis. Tetracycline is the treatment of choice for moderate to severe: acne and is given in the dosage of 250 mg three to four times daily with a gradual reduction to a maintenance dose of 250 mg once a day for several months, Recently, oral retinoid (isotretinoin) has been found to be very effective drug in the management of severe form of acne, especially nodulo cystic acne and conglobata. Anti androgens like cyproterone acetate and spironolactone are also beneficial in treatment of acne. Females with recalcitrant and severe type of acne usually require oestrogens either in the form of oral con¬traceptives or in combination with antiandrogens.
Acne Causes - Culprit : Follicle fallout. Normally, dead cells within the follicle shed gradually and are expelled onto the skin's surface. But in patients with overactive sebaceous glands — and in nearly everyone during puberty — these cells are shed more rapidly. Mixed with a surplus of sebum, the dead skin cells form a plug in the follicle, preventing the skin from finishing its natural process of renewal.
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